Tubacin

(HB1403)

Product overview

  • Name
    Tubacin
  • Short description
    Selective HDAC6 inhibitor
  • Biological description
    Selective histone deacetylase 6 (HDAC6) inhibitor. Selective for HDAC6 over HDAC3, 8, 1, 5, 10, 11, 9, 2, 7 and 4 (IC50 values are 4 nM and 1.27, 1.27, 1.4, 3.35, 3.71, 3.79, 4.31, 6.27, 9.7 and 17.3 µM respectively). Induces tubulin acetylation. Shows anti-cancer, anti-proliferative and apoptotic actions.
  • Alternative names
    Tubulin acetylation inducer
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl- 2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl ]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
  • Molecular Weight
    721.86
  • Chemical structure
    Tubacin  [1350555-93-9]
  • Molecular Formula
    C41H43N3O7S
  • CAS Number
    1350555-93-9

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Tubacin

  • Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.

    Butler KV et al (2010) J Am Chem Soc 132(31) : 10842-6.
    PubMedID: 20614936
  • Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation.

    Haggarty SJ et al (2003) Proc Natl Acad Sci U S A 100(8) : 4389-94.
    PubMedID: 12677000
  • Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.

    Aldana-Masangkay GI et al (2011) Leuk Lymphoma 52(8) : 1544-55.
    PubMedID: 21699378
  • Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis.

    Kawada J et al (2009) J Biol Chem 284(25) : 17102-9.
    PubMedID: 19386607

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