Product overview

Name Tubacin
Alternative names Tubulin acetylation inducer
Purity >98%
Description Selective HDAC6 inhibitor
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Biological Data

Biological description Selective histone deacetylase 6 (HDAC6) inhibitor. Selective for HDAC6 over HDAC3, 8, 1, 5, 10, 11, 9, 2, 7 and 4 (IC50 values are 4 nM and 1.27, 1.27, 1.4, 3.35, 3.71, 3.79, 4.31, 6.27, 9.7 and 17.3 µM respectively). Induces tubulin acetylation. Shows anti-cancer, anti-proliferative and apoptotic actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >98%
Chemical name N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl- 2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl ]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
Molecular Weight 721.86
Chemical structure Tubacin  [1350555-93-9] Chemical Structure
Molecular Formula C41H43N3O7S
CAS Number 1350555-93-9
PubChem identifier 6675804
SMILES OCC(C=C4)=CC=[C@@]4[C@@H]1C[C@H](CSC2=NC(C6=CC=CC=C6)=C(C5=CC=CC=C5)O2)O[C@H]([C@]3=CC=C(NC(CCCCCCC(NO)=O)=O)C=C3)O1
InChiKey BHUZLJOUHMBZQY-YXQOSMAKSA-N

References for Tubacin

References are publications that support the biological activity of the product
  • Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.

    Aldana-Masangkay GI et al (2011) Leuk Lymphoma 52(8) : 1544-55.
  • Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.

    Butler KV et al (2010) J Am Chem Soc 132(31) : 10842-6.
  • Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis.

    Kawada J et al (2009) J Biol Chem 284(25) : 17102-9.
  • Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation.

    Haggarty SJ et al (2003) Proc Natl Acad Sci U S A 100(8) : 4389-94.

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