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(+)-Tubocurarine chloride

(HB2050)
Data

Product overview

  • Name
    (+)-Tubocurarine chloride
  • Short description
    Nicotinic acetylcholine receptors (nACHR) antagonist. Neuromuscular blocker.
  • Biological description

    Tubocurarine is a competitive, non-selective nicotinic acetylcholine receptors (nACHR) antagonist which blocks neuromuscular transmission.

    Tubocurarine is also a GABAA and 5-HT3 receptor antagonist.

  • Alternative names
    DTC, d-tubocurarine
  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (13aR,25aS)-2,3,13a,14,15,16,25,25a-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride pentahydrate
  • Molecular Weight
    771.72
  • Chemical structure
    (+)-Tubocurarine [6989-98-6]
  • Molecular Formula
    C37H41ClN2O6.HCl.5H2O
  • CAS Number
    6989-98-6
  • PubChem identifier
    23422
  • SMILES
    CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C6[C@@H](CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC.O.O.O.O.O.Cl.[Cl-]
  • InChi
    InChI=1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;;
  • InChiKey
    WMIZITXEJNQAQK-GGDSLZADSA-N
  • MDL number
    MFCD00150157
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in water (25 mM), and in DMSO (10 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for (+)-Tubocurarine chloride

  • Pre-and post-junctional effects of tubocurarine and other nicotinic antagonists during repetitive stimulation in the rat.

    Gibb and Marhsall (1984) J Physiol 351 : 275-97
    PubMedID: 6747867
  • The actions of tubocurarine at the frog neuromuscular junction.

    Colquhoun et al (1979) J Physiol. 293 : 247-84
    PubMedID: 315462
  • The effect of (+)-tubocurarine on neuromuscular transmission during repetitive stimulation in the rat, mouse, and frog.

    Magleby et al (1981) J Physiol. 312 : 97-113
    PubMedID: 6267269
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