Tunicamycin

(HB0880)

Product overview

  • Name
    Tunicamycin
  • Short description
    GlcNAc phosphotransferase inhibitor
  • Biological description
    GlcNAc phosphotransferase (GPT) inhibitor. Inhibits glycoprotein synthesis. Causes endoplasmic reticulum stress and apoptosis. Shows antibiotic and anticancer actions.
  • Biological action
    Inhibitor
  • Our products in action

Properties

  • Chemical name
    Tunicamycin from Streptomyces sp.
  • Molecular Weight
    844.95
  • Molecular Formula
    C39H64N4O16 (tunicamycin C, n=10)
  • CAS Number
    11089-65-9

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (50mM)

References for Tunicamycin

  • Dipeptidyl petidase-IV inhibitor (gemigliptin) inhibits tunicamycin-induced endoplasmic reticulum stress, apoptosis and inflammation in H9c2 cardiomyocytes.

    Hwang HJ et al (2014) Mol Cell Endocrinol 392(1-2) : 1-7.
    PubMedID: 24813659
  • Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival.

    Ding WX et al (2007) J Biol Chem 282(7) : 4702-10.
    PubMedID: 17135238
  • Tunicamycin potentiates cisplatin anticancer efficacy through the DPAGT1/Akt/ABCG2 pathway in mouse Xenograft models of human hepatocellular carcinoma.

    Hou H et al (2013) Mol Cancer Ther 12(12) : 2874-84.
    PubMedID: 24130050

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