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Data

Product overview

  • Name
    Tunicamycin
  • Short description
    ER Stress inducer which induces cell death
  • Biological description

    Tunicamycin is an antibiotic which is commonly used to induce ER (endoplasmic reticulum) stress and activate the unfolded protein response (UPR) to induce cell death.


    Tunicamycin inhibits the DPAGT1 enzyme to inhibit one of the first steps of glycoprotein biosynthesis in the ER which results in the accumulation of misfolded proteins to cause subsequent ER stress.


    ER stress can often be induced by treating cells with tunicamycin at 2.5-5 µg/ml of tunicamycin for 5 hours.

  • Alternative names
    TUN, TM
  • Biological action
    Inhibitor
  • Citations

Properties

  • Chemical name
    Tunicamycin from Streptomyces sp.
  • Molecular Weight
    844.95
  • Chemical structure
    Tunicamycin  [11089-65-9]
  • Molecular Formula
    C39H64N4O16 (tunicamycin C, n=10)
  • CAS Number
    11089-65-9
  • Source
    Streptomyces sp
  • MDL number
    MFCD00065709
  • Appearance
    Off-white solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Tunicamycin

  • Dipeptidyl petidase-IV inhibitor (gemigliptin) inhibits tunicamycin-induced endoplasmic reticulum stress, apoptosis and inflammation in H9c2 cardiomyocytes.

    Hwang HJ et al (2014) Mol Cell Endocrinol 392(1-2) : 1-7.
    PubMedID: 24813659
  • Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival.

    Ding WX et al (2007) J Biol Chem 282(7) : 4702-10.
    PubMedID: 17135238
  • Tunicamycin potentiates cisplatin anticancer efficacy through the DPAGT1/Akt/ABCG2 pathway in mouse Xenograft models of human hepatocellular carcinoma.

    Hou H et al (2013) Mol Cancer Ther 12(12) : 2874-84.
    PubMedID: 24130050
  • Tunicamycin induced endoplasmic reticulum stress promotes apoptosis of prostate cancer cells by activating mTORC1.

    Guha et al (2017) Oncotarget 8(40) : 68191-68207
    PubMedID: 28978108
  • A novel endoplasmic reticulum stress‑induced apoptosis model using tunicamycin in primary cultured neonatal rat cardiomyocytes.

    Shen et al (2015) Mol Med Rep 12(4) : 5149-54
    PubMedID: 26151415
  • SEC24A identified as an essential mediator of thapsigargin-induced cell death in a genome-wide CRISPR/Cas9 screen.

    Chidawanyika et al (2018) Cell Death Dis : doi: 10.1038/s41420-018-0135-5
    PubMedID: 30588337
  • Measuring ER stress and the unfolded protein response using mammalian tissue culture system.

    Oslowski and Urano (2011) Methods Enzymol 490 : 71-92
    PubMedID: 21266244
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