TX-1123

(HB0622)

Product overview

  • Name
    TX-1123
  • Short description
    Tyrosine kinase inhibitor
  • Biological description
    Tyrosine kinase inhibitor. Inhibits Src, eEF2-K, and PKA (IC50 values are 2.2, 3.2 and 9.6 mM respectively). Shows anti-tumor actions and acts as an antiangiogenic hypoxic cell radiosensitizer.
  • Biological action
    Inhibitor
  • Citations

Properties

  • Chemical name
    2-((3,5-di-tert-Butyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione
  • Molecular Weight
    312.4
  • Chemical structure
    TX-1123  [157397-06-3]
  • Molecular Formula
    C20H24O3
  • CAS Number
    157397-06-3

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (10mg/ml)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for TX-1123

  • TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity.

    Hori H et al (2002) Bioorg Med Chem 10(10) : 3257-65.
    PubMedID: 12150871
  • Design of hypoxia-targeting protein tyrosine kinase inhibitor using an innovative pharmacophore 2-methylene-4-cyclopentene-1,3-dione.

    Hori H et al (2004) Biochim Biophys Acta 1697(1-2) : 29-38.
    PubMedID: 15023348
  • Chemical properties and biological activities of cyclopentenediones: a review.

    Sevcíková Z et al (2014) Mini Rev Med Chem 14(4) : 322-31.
    PubMedID: 24605879

Reviews & Product Guides