U0126

(HB2246)

Product overview

  • Name
    U0126
  • Short description
    Potent, selective MEK-1/MEK-2 inhibitor
  • Biological description
    Potent, selective and non-competitive MAP kinase kinase (MAP2K) inhbitor. Inhibits both MEK-1 and MEK-2 (IC50 values are 72 and 58 nM respectively) while showing little or no effect on many other kinases. Inhibits AP-1 transactivation and shows many other actions. Active in vivo.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Images

Properties

  • Chemical name
    1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
  • Molecular Weight
    380.48
  • Chemical structure
    U0126 [109511-58-2]
  • Molecular Formula
    C18H16N6S2
  • CAS Number
    109511-58-2
  • PubChem identifier
    3006531
  • SMILES
    C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N
  • InChi
    InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
  • InChiKey
    DVEXZJFMOKTQEZ-JYFOCSDGSA-N
  • MDL number
    MFCD25977152

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for U0126

  • MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.

    Duncia JV et al (1998) Bioorg Med Chem Lett 8(20) : 2839-44.
    PubMedID: 9873633
  • Identification of a novel inhibitor of mitogen-activated protein kinase kinase.

    Favata MF et al (1998) J Biol Chem 273(29) : 18623-32.
    PubMedID: 9660836
  • Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model.

    Duan W et al (2004) J Immunol 172(11) : 7053-9.
    PubMedID: 15153527
  • Pre-LTP requires extracellular signal-regulated kinase in the ACC.

    Yamanaka et al (2016) Mol Pain 12 : 1-12
    PubMedID: 27178245
The following papers have cited the use of U0126 (HB2246) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Pre-LTP requires extracellular signal-regulated kinase in the ACC.

    Yamanaka et al (2016) Mol Pain 12 : 1-12
    PubMedID: 27178245

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