Product overview

Name UBP 302
Purity >98%
Description Potent, selective GluK1 subunit selective kainate receptor antagonist
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Biological Data

Biological description Potent and selective GluK1 (formerly GluR5) subunit selective kainate receptor antagonist (apparent KD = 402 nM). Active enantiomer of UBP 296. Shows anxiolytic effects.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in NaOH(aq) (25mM, gentle warming) or DMSO (20mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione
Molecular Weight 333.3
Chemical structure UBP 302  [745055-91-8] Chemical Structure
Molecular Formula C15H15N3O6
CAS Number 745055-91-8
PubChem identifier 6420161
SMILES O=C(C=CN(C[C@H](N)C(O)=O)C2=O)N2CC1=CC=CC=C1C(O)=O
InChiKey UUIYULWYHDSXHL-NSHDSACASA-N

References for UBP 302

References are publications that support the biological activity of the product
  • Presynaptic facilitation of glutamate release in the basolateral amygdala: a mechanism for the anxiogenic and seizurogenic function of GluK1 receptors.

    Aroniadou-Anderjaska V et al (2012) Neuroscience 221 : 157-69.
  • Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.

    Dolman NP et al (2005) J Med Chem 48(24) : 7867-81.
  • Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist.

    More JC et al (2004) Neuropharmacology 47(1) : 46-64.

3 Item(s)