UBP 310

(HB0628)

Product overview

  • Name
    UBP 310
  • Short description
    Potent, selective GluK1 / GluK3 subunit selective kainate receptor antagonist
  • Biological description
    Potent and selective GluK1 (formerly GluR5) and GluK3 (formerly GluR7) subunit selective kainate receptor antagonist (Kb = 10 nM and IC50 = 23 nM respectively). IC50 values are > 100 µM for GluA2, GluK6, GluK2/3 and GluK6/GluK2 respectively. Active at AMPA receptors and inactive against NMDA and Group I mGlu receptors at concentrations of up to 10 µM.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (S)-1-(2-Amino-2-carboxyethyl)-3-(2 -carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione
  • Molecular Weight
    353.35
  • Chemical structure
    UBP 310  [902464-46-4]
  • Molecular Formula
    C14H15N3O6S
  • CAS Number
    902464-46-4
  • PubChem identifier
    6420160
  • SMILES
    CC1=CN(C(=O)N(C1=O)CC2=C(SC=C2)C(=O)O)C[C@@H](C(=O)O)N
  • InChi
    InChI=1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1
  • InChiKey
    ZTAZUCRXCRXNSU-VIFPVBQESA-N

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for UBP 310

  • Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.

    Mayer ML et al (2006) J Neurosci 26(11) : 2852-61.
    PubMedID: 16540562
  • Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists.

    Dolman NP et al (2007) J Med Chem 50(7) : 1558-70.
    PubMedID: 17348638
  • Antagonism of recombinant and native GluK3-containing kainate receptors.

    Perrais D et al (2009) Neuropharmacology 56(1) : 131-40.
    PubMedID: 18761361