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Product overview

  • Name
  • Short description
    Novel NMDAR pan-PAM
  • Biological description

    UBP684 is a novel NMDAR PAM (positive allosteric modulator) which robustly potentiates responses at all GluN1/GluN2 subtypes and at neuronal NMDARs. UBP684 increases the maximal l-glutamate/glycine response while having minor subunit-specific effects on agonist potency.

    UBP684 increases NMDAR channel open probability (Po) and slows receptor deactivation time upon removal of L-glutamate but not glycine.

    Docking studies suggest that UBP684 binds to the GluN1 and GluN2 LBD (ligand binding domain) interface supporting its potential ability in stabilizing the LBD closed conformation.

    UBP684 binding is independent of agonist binding and its activity is independent of membrane voltage and redox state. UBP684 activity is also pH-dependent, with enhanced potentiation at lower pHs and inhibitory activity at high pH (e.g.8.4).

  • Purity
  • Citations



  • Chemical name
    6-(4-methylpentyl)naphthalene-2-carboxylic acid
  • Molecular Weight
  • Chemical structure
    UBP 684
  • Molecular Formula
  • Source
  • InChi
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    Soluble in DMSO (100 mM)
  • Handling

    University of Nebraska researchers recommend making up UBP684 as a 50 mM stock solution in DMSO and diluting it into physiological buffer up to 50 µM.

    Please note that UBP684 is less soluble in physiological buffers that have mM levels of calcium.

    UBP684 can be used in buffers usually used for studying NMDAR responses in Xenopus oocytes, however it may not work well in buffers used to investigate synaptic transmission.

    Calcium-free buffers can be used to improve compound solubility.

  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for UBP684

  • Gating Effects of a Novel Allosteric Modulator at GluN1/GluN2A NMDA Receptors

    Chopra et al (2015) FASEB 29 no.1 : Supplement 933.3
  • Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives.

    Sapkota et al (2017) Neuropharmacology 125: : 64-79
    PubMedID: 28709671
  • A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors.

    Chopra et al (2017) Sci Rep. 7(1) : 6933
    PubMedID: 28761055
Support & Resources


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