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Product overview

  • Name
    UCPH 101
  • Short description
    UCPH-101 is a potent, selective, non-competitive EAAT1 inhibitor
  • Biological description

    UCPH-101 is a potent, selective, non-competitive inhibitor of the EAAT1 (Excitatory Amino Acid Transporter 1) glutamate transporter (IC50 = 660 nM). UCPH-101 shows >400-fold selectivity for EAAT1 over EAAT2 and EAAT3 and shows no inhibitory activity at EAAT4 and EAAT5 in a patch-clamp electrophysiology assay (in which final concentration was up to 10 μM). UCPH-102 which is blood brain barrier permeable is now also available.

  • Biological action
  • Purity
  • Citations


  • Chemical name
    2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene- 3-carbonitrile
  • Molecular Weight
  • Chemical structure
    UCPH 101  [1118460-77-7]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    Soluble in DMSO (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for UCPH 101

  • Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1.

    Jensen AA et al (2009) J Med Chem 52(4) : 912-5.
    PubMedID: 19161278
  • Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102.

    Huynh TH et al (2012) Bioorg Med Chem 20(23) : 6831-9.
    PubMedID: 23072958
  • Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain.

    Abrahamsen B et al (2013) J Neurosci 33(3) : 1068-87.
    PubMedID: 23325245
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