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Data

Product overview

  • Name
    UCPH-102
  • Short description
    Selective EAAT1 inhibitor
  • Biological description

    UCPH-102 an analog of UCPH-101 and is a selective inhibitor of the glutamate transporter EAAT1 (excitatory amino acid transporter subtype 1) (IC50 = 0.42 µM and >300 µM at EAAT2-5). UCPH-102 is blood-brain barrier permeable (unlike UCPH-101) and active in vivo

  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    2-Amino-5,6,7,8-tetrahydro-4-methyl-7-(1-naphthalenyl)-5-oxo-4H-1-benzopyran-3-carbonitrile
  • Molecular Weight
    330.39
  • Chemical structure
    UCPH 102 [1229591-56-3]
  • Molecular Formula
    C21H18N2O2
  • CAS Number
    1229591-56-3
  • PubChem identifier
    46215971
  • SMILES
    CC1C(=C(OC2=C1C(=O)CC(C2)C3=CC=CC4=CC=CC=C43)N)C#N
  • Source
    Synthetic
  • InChi
    InChI=1S/C21H18N2O2/c1-12-17(11-22)21(23)25-19-10-14(9-18(24)20(12)19)16-8-4-6-13-5-2-3-7-15(13)16/h2-8,12,14H,9-10,23H2,1H3
  • InChiKey
    XZQMHUGTNOOYFX-UHFFFAOYSA-N
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (25 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for UCPH-102

  • Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs.

    Erichsen et al (2014) Neurochem Res 39(10) : 1964-79
    PubMedID: 24682739
  • Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102.

    Huynh et al (2012) Bioorg Med Chem Lett 20(23) : 6831-9
    PubMedID: 23072958
  • Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain.

    Abrahamsen et al (2013) J Neurosci 33(3) : 1068-87
    PubMedID: 23325245
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