UNC 0224

(HB1420)

Product overview

  • Name
    UNC 0224
  • Short description
    Potent, selective G9a HMTase inhibitor
  • Biological description
    Potent and selective G9a histone lysine methyltransferase (HMTase) inhibitor (IC50 = 15 nM).
  • Alternative names
    Compound 8
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    7-[3-(Dimethylamino)propoxy]-2-(hex ahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N- (1-methyl-4-piperidinyl)-4-quinazolinamine
  • Molecular Weight
    485.67
  • Chemical structure
    UNC 0224  [1197196-48-7]
  • Molecular Formula
    C26H43N7O2
  • CAS Number
    1197196-48-7

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for UNC 0224

  • Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.

    Liu F et al (2009) J Med Chem 52(24) : 7950-3.
    PubMedID: 19891491
  • Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.

    Liu F et al (2010) J Med Chem 53(15) : 5844-57.
    PubMedID: 20614940

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