Product overview

Name UNC 0224
Alternative names Compound 8
Purity >98%
Description Potent, selective G9a HMTase inhibitor
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Biological Data

Biological description Potent and selective G9a histone lysine methyltransferase (HMTase) inhibitor (IC50 = 15 nM).

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >98%
Chemical name 7-[3-(Dimethylamino)propoxy]-2-(hex ahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N- (1-methyl-4-piperidinyl)-4-quinazolinamine
Molecular Weight 485.67
Chemical structure UNC 0224  [1197196-48-7] Chemical Structure
Molecular Formula C26H43N7O2
CAS Number 1197196-48-7
PubChem identifier 44251522
SMILES CN(CC4)CCC4NC1=C2C(C=C(OCCCN(C)C)C(OC)=C2)=NC(N3CCCN(C)CC3)=N1
InChiKey XIVUGRBSBIXXJE-UHFFFAOYSA-N

References for UNC 0224

References are publications that support the biological activity of the product
  • Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.

    Liu F et al (2010) J Med Chem 53(15) : 5844-57.
  • Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.

    Liu F et al (2009) J Med Chem 52(24) : 7950-3.

2 Item(s)