UNC 0646

(HB1423)

Product overview

  • Name
    UNC 0646
  • Short description
    Potent, selective G9a / GLP HMTase inhibitor
  • Biological description
    Potent and selective G9a and G9a-like protein (GLP) histone lysine methyltransferase (HMTase) inhibitor (IC50 values are 6 and < 15 nM respectively). Selective for G9a and GLP over other methyltransferases.
  • Alternative names
    Compound 6
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6 -methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolin amine
  • Molecular Weight
    621.9
  • Chemical structure
    UNC 0646  [1320288-17-2]
  • Molecular Formula
    C36H59N7O2
  • CAS Number
    1320288-17-2

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for UNC 0646

  • Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.

    Liu F et al (2011) J Med Chem 54(17) : 6139-50.
    PubMedID: 21780790
  • G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes.

    Bittencourt D et al (2012) Proc Natl Acad Sci U S A 109(48) : 19673-8.
    PubMedID: 23151507

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