Valproic acid sodium salt

(HB0867)

Product overview

  • Name
    Valproic acid sodium salt
  • Short description
    Histone deacetylase inhibitor. Shows multitude of biological actions. Enables pluripotent stem cell induction from somatic cells.
  • Biological description
    Histone deacetylase inhibitor (IC50 = 400 µM at HDAC1). Shows multitude of biological actions. Can be used to produce pluripotent stem cells (iPS cells) with only Oct4 and Sox2 factors required in addition. Activates Wnt-dependent gene expression and shows anti-inflammatory, anti-cancer anti-epileptic and neuroprotective actions. Blood-brain barrier permeable .
  • Alternative names
    VPA
  • Biological action
    Inhibitor
  • Citations

Properties

  • Chemical name
    Sodium 2-propylpentanoate
  • Molecular Weight
    166.19
  • Chemical structure
    Valproic acid sodium salt  [1069-66-5]
  • Molecular Formula
    C8H15NaO2
  • CAS Number
    1069-66-5

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in water (100mM) or DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Valproic acid sodium salt

  • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.

    Phiel CJ et al (2001) J Biol Chem 276(39) : 36734-41.
    PubMedID: 11473107
  • Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models.

    Qing H et al (2008) J Exp Med 205(12) : 2781-9.
    PubMedID: 18955571
  • Potentiation of anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the cyclin-dependent kinase inhibitor P276-00 in human non-small-cell lung cancer cell lines.

    Shirsath N et al (2013) Lung Cancer 82(2) : 214-21.
    PubMedID: 24051085
  • Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.

    Huangfu D et al (2008) Nat Biotechnol 26(11) : 1269-75.
    PubMedID: 18849973