Product overview

Name Valsartan
Purity >98%
Description Selective angiotensin AT1 antagonist
Write Your Own Review
You're reviewing:Valsartan
Rate this item:

Biological Data

Biological description

Selective angiotensin AT1 antagonist (IC50 = 44.9 nM) that displays ~30,000-fold selectivity over AT2 receptors.

Shows anti-hypertensive effects.

Recently investigated as part of COVID-19 compound repurposing.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name (S)-3-methyl-2-(N-{[2'-(2H-1,2,3,4-tetrazol-5-yl)biphenyl-4-yl]methyl}pentanamido)butanoic acid
Molecular Weight 435.52
Chemical structure Valsartan [137862-53-4] Chemical Structure
Molecular Formula C24H29N5O3
CAS Number 137862-53-4
PubChem identifier 60846
SMILES CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O
InChi InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1
InChiKey ACWBQPMHZXGDFX-QFIPXVFZSA-N
MDL number MFCD00865840
Appearance White solid

References for Valsartan

References are publications that support the biological activity of the product
  • Valsartan: more than a decade of experience

    Black HR et al (2009) Drugs 69(17) : 2393-414
  • Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype

    Criscione L et al (1993) Br J Pharmacol 110(2) : 761-71

2 Item(s)