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Verapamil hydrochloride

(HB1237)
Data

Product overview

  • Name
    Verapamil hydrochloride
  • Short description
    L-type Ca2+ channel blocker
  • Biological description
    L-type Ca2+ channel blocker. Increases FRZB expression and decreases Wnt/β-catenin signalling in osteoarthritis. Adrenergic antagonist. Shows cartilage protective, vasodilator, anti-arrhythmic, anti-oxidative stress and cardioprotective actions.
  • Biological action
    Blocker
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl) benzeneacetonitrile hydrochloride
  • Molecular Weight
    491.07
  • Chemical structure
    Verapamil hydrochloride  [152-11-4]
  • Molecular Formula
    C27H38N2O4.HCl
  • CAS Number
    152-11-4
  • PubChem identifier
    62969
  • SMILES
    CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl
  • InChi
    InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
  • InChiKey
    DOQPXTMNIUCOSY-UHFFFAOYSA-N
  • MDL number
    MFCD00055208

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Verapamil hydrochloride

  • Comparative study of the effect of verapamil and vitamin D on iron overload-induced oxidative stress and cardiac structural changes in adult male rats.

    Abd Allah ES et al (2014) Pathophysiology :
    PubMedID: 25092628
  • Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.

    Takamatsu A et al (2014) PLoS One 9(3) : e92699.
    PubMedID: 24658359
  • Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.

    Oros A et al (2010) Br J Pharmacol 161(1) : 162-75.
    PubMedID: 20718748
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