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Veratridine

(HB1006)
Data

Product overview

  • Name
    Veratridine
  • Short description
    Na+ channel activator
  • Biological description
    Na+ channel activator. Binds to active channels and prevents the inactive state. Increases persistent sodium current and intracellular Ca2+. Increases reverse Na+ / Ca2+ exchange current, pump activity and exocytosis. Induces action potentials and extended membrane depolarization.
  • Biological action
    Activator
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β, 12,14,16β,17,20-hexaol
  • Molecular Weight
    673.79
  • Chemical structure
    Veratridine  [71-62-5]
  • Molecular Formula
    C36H51NO11
  • CAS Number
    71-62-5

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Veratridine

  • Effects of veratridine on sodium currents and fluxes.

    Ulbricht W (1998) Rev Physiol Biochem Pharmacol 133 : 1-54.
    PubMedID: 9600010
  • Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy.

    Fekete A et al (2009) J Neurochem 111(3) : 745-56.
    PubMedID: 19719824
  • Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine.

    Maroto R et al (1994) Eur J Pharmacol 270(4) : 331-9.
    PubMedID: 7805782
  • [Involvement of veratridine-induced increase of reverse Na(+)/Ca(2+) exchange current in intracellular Ca(2+) overload and extension of action potential duration in rabbit ventricular myocytes].

    Kong LH et al (2012) Sheng Li Xue Bao 64(4) : 433-43.
    PubMedID: 22907304
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