Product overview

Name Verruculogen
Purity >98%
Description Selective KCa1. 1 channel blocker
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Biological Data

Biological description Fumitremorgin-type alkaloid. Tremorgenic neurotoxic mycotoxin. Selective blocker of KCa1. 1 (high-conductance Ca2+-activated K+; BK; maxi-K) channels. Decreases GABA levels in CNS. Increases spontaneous glutamate and aspartate release. At toxic doses, increases the number and decreases the affinity of DHP receptors in rat cortex. Cell cycle inhibitor at the M phase. Inhibits calmodulin and PKC activity. Has apoptotic effects on human T lymphocytes. Stimulates the growth of seedling roots of buckwheat.

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Molecular Weight 511.6
Chemical structure Verruculogen [12771-72-1] Chemical Structure
CAS Number 12771-72-1
SMILES COc1ccc2c(c1)n3C(OOC(C)(C)CC4N5C(=O)C6CCCN6C(=O)C5(O)C(O)c2c34)C=C(C)C
InChiKey LRXYHMMJJCTUMY-GWXUGYLUSA-N
Appearance White to off-white solid