Vigabatrin

(HB0868)

Product overview

  • Name
    Vigabatrin
  • Short description
    Selective, irreversible GABA-T (transaminase) inhibitor
  • Biological description
    Selective and irreversible GABA-T (transaminase) inhibitor. Inhibits GABA catabolism. Increases GABA levels in the brain and CSF while decreasing glutamate in a dose-dependent manner. Shows anticonvulsant and antidepressant actions.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    4-Aminohexenoic acid
  • Molecular Weight
    129.16
  • Chemical structure
    Vigabatrin  [60643-86-9]
  • Molecular Formula
    C6H11NO2
  • CAS Number
    60643-86-9

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Vigabatrin

  • Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurones and astrocytes.

    Larsson OM et al (1986) Neuropharmacology 25(6) : 617-25.
    PubMedID: 3092125
  • Effects of vigabatrin (gamma-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats.

    Halonen T et al (1991) Epilepsia 32(2) : 242-9.
    PubMedID: 1672276
  • Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity.

    Russo E et al (2011) Behav Brain Res 225(1) : 373-6.
    PubMedID: 21807031

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