VU 0357017 hydrochloride

(HB1498)

Product overview

  • Name
    VU 0357017 hydrochloride
  • Short description
    Potent, selective M1 receptor allosteric agonist
  • Biological description
    Potent and selective M1 muscarinic receptor allosteric agonist (EC50 = 198 nM). Binds to the orthosteric ACh site at high concentrations to act as an antagonist. Reverses contextual fear conditioning deficits. Shows cognitive enhancing actions. Blood-brain barrier permeable.
  • Biological action
    Agonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    4-[[2-[(2-Methylbenzoyl)amino]ethyl ]amino]-1-piperidinecarboxylic acid ethyl ester hydrochloride
  • Molecular Weight
    369.89
  • Chemical structure
    VU 0357017 hydrochloride  [1135242-13-5]
  • Molecular Formula
    C18H27N3O3.HCl
  • CAS Number
    1135242-13-5

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in water (25mM) or DMSO (5mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for VU 0357017 hydrochloride

  • Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.

    Lebois EP et al (2010) ACS Chem Neurosci 1(2) : 104-121.
    PubMedID: 21961051
  • Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.

    Digby GJ et al (2012) J Neurosci 32(25) : 8532-44.
    PubMedID: 22723693
  • Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.

    Sheffler DJ et al (2013) Bioorg Med Chem Lett 23(1) : 223-7.
    PubMedID: 23200253

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