VU 0360223

(HB0637)

Product overview

  • Name
    VU 0360223
  • Short description
    mGlu5 negative allosteric modulator
  • Biological description
    mGlu5 receptor negative allosteric modulator (IC50 = 61 nM). Exhibits little or no activity at mGlu1-4 and mGlu7-8 receptors. Blood-brain barrier permeable.
  • Biological action
    NAM
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    3-Fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile
  • Molecular Weight
    268.31
  • Chemical structure
    VU 0360223  [1274859-33-4]
  • Molecular Formula
    C15H9FN2S
  • CAS Number
    1274859-33-4

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for VU 0360223

  • (3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction.

    Lindsley CW et al (2011) ACS Chem Neurosci 2(8) : 471-482.
    PubMedID: 21927650