Product overview

Name VU 0360223
Purity >99%
Description mGlu5 negative allosteric modulator
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Biological Data

Biological description mGlu5 receptor negative allosteric modulator (IC50 = 61 nM). Exhibits little or no activity at mGlu1-4 and mGlu7-8 receptors. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >99%
Chemical name 3-Fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile
Molecular Weight 268.31
Chemical structure VU 0360223  [1274859-33-4] Chemical Structure
Molecular Formula C15H9FN2S
CAS Number 1274859-33-4
PubChem identifier 45103530
SMILES CC2=NC1=CC(C3=CC(F)=CC(C#N)=C3)=CC=C1S2
InChiKey WDHYUBIJZHYUOV-UHFFFAOYSA-N

References for VU 0360223

References are publications that support the biological activity of the product
  • (3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction.

    Lindsley CW et al (2011) ACS Chem Neurosci 2(8) : 471-482.

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