VU 0361737

(HB0638)

Product overview

  • Name
    VU 0361737
  • Short description
    mGlu4 positive allosteric modulator
  • Biological description
    mGlu4 receptor positive allosteric modulator (EC50 = 0.24 µM). Displays little activity at mGlu5 and mGlu8 receptors and no activity at mGlu1, 2, 3, 6 and 7 receptors. Blood-brain barrier permeable.
  • Biological action
    PAM
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
  • Molecular Weight
    262.69
  • Chemical structure
    VU 0361737  [1161205-04-4]
  • Molecular Formula
    C13H11ClN2O2
  • CAS Number
    1161205-04-4

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM)

References for VU 0361737

  • Radiosynthesis of N-(4-chloro-3-[(11)C]methoxyphenyl)-2-picolinamide ([(11)C]ML128) as a PET radiotracer for metabotropic glutamate receptor subtype 4 (mGlu4).

    Kil KE et al (2013) Bioorg Med Chem 21(19) : 5955-62.
    PubMedID: 23978356
  • Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.

    Engers DW et al (2011) J Med Chem 54(4) : 1106-10.
    PubMedID: 21247167
  • Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).

    Engers DW et al (2009) J Med Chem 52(14) : 4115-8.
    PubMedID: 19469556