Product overview

Name VU 0364439
Purity >99%
Description Potent mGlu4 positive allosteric modulator
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Biological Data

Biological description Potent mGlu4 receptor positive allosteric modulator (EC50 = 19.8 nM).

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >99%
Chemical name N-[3-Chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamide
Molecular Weight 422.29
Chemical structure VU 0364439  [1246086-78-1] Chemical Structure
Molecular Formula C18H13Cl2N3O3S
CAS Number 1246086-78-1
PubChem identifier 46934289
SMILES O=C(NC2=CC(Cl)=C(S(NC3=C(Cl)C=CC=C3)(=O)=O)C=C2)C1=NC=CC=C1
InChiKey IXHCGJXBIHHIEF-UHFFFAOYSA-N

References for VU 0364439

References are publications that support the biological activity of the product
  • Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS).

    Engers DW et al (2010) Bioorg Med Chem Lett 20(17) : 5175-8.

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