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VU 0364770


Product overview

  • Name
    VU 0364770
  • Short description
    mGlu4 positive allosteric modulator
  • Biological description
    mGlu4 receptor positive allosteric modulator (EC50 = 0.29 µM). Displays high affinity for MAO-B over MAO-A (Ki values are 0.72 and 8.5 µM respectively). Exhibits weak PAM activity at mGlu6 receptor and antagonist activity at mGlu5. Blood brain barrier permeable. Reverses forelimb asymmetry and haloperidol-induced catalepsy in rats.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    VU 0364770  [61350-00-3]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for VU 0364770

  • The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

    Jones CK et al (2012) J Pharmacol Exp Ther 340(2) : 404-21.
    PubMedID: 22088953
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