Product overview

Name VU 0364770
Purity >99%
Description mGlu4 positive allosteric modulator
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Biological Data

Biological description mGlu4 receptor positive allosteric modulator (EC50 = 0.29 µM). Displays high affinity for MAO-B over MAO-A (Ki values are 0.72 and 8.5 µM respectively). Exhibits weak PAM activity at mGlu6 receptor and antagonist activity at mGlu5. Blood brain barrier permeable. Reverses forelimb asymmetry and haloperidol-induced catalepsy in rats.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >99%
Chemical name N-(3-Chlorophenyl)-2-pyridinecarboxamide
Molecular Weight 232.67
Chemical structure VU 0364770  [61350-00-3] Chemical Structure
Molecular Formula C12H9ClN2O
CAS Number 61350-00-3
PubChem identifier 836002
SMILES O=C(C2=NC=CC=C2)NC1=CC=CC(Cl)=C1
InChiKey SUYUTNCKIOLMAJ-UHFFFAOYSA-N

References for VU 0364770

References are publications that support the biological activity of the product
  • The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

    Jones CK et al (2012) J Pharmacol Exp Ther 340(2) : 404-21.

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