VU 29

(HB0642)

Product overview

  • Name
    VU 29
  • Short description
    Potent mGlu5 positive allosteric modulator
  • Biological description
    Potent mGlu5 receptor positive allosteric modulator (EC50 = 9 nM). Selectively potentiates mGlu5 over mGlu1 and mGlu2 receptors (EC50 values are 557 nM and 1.51 µM for mGlu1 and mGlu2 receptors respectively). Shows agonistic properties for N-Terminal truncated mGlu5 receptor. CDPPB analog.
  • Biological action
    PAM
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide
  • Molecular Weight
    384.39
  • Chemical structure
    VU 29  [890764-36-0]
  • Molecular Formula
    C22H16N4O3
  • CAS Number
    890764-36-0
  • PubChem identifier
    11610682
  • SMILES
    C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=C(C=C3)[N+](=O)[O-])C4=CC=CC=C4
  • Source
    Synthetic
  • InChi
    InChI=1S/C22H16N4O3/c27-22(17-11-13-19(14-12-17)26(28)29)23-21-15-20(16-7-3-1-4-8-16)24-25(21)18-9-5-2-6-10-18/h1-15H,(H,23,27)
  • InChiKey
    KIALCSMRIHRFPL-UHFFFAOYSA-N
  • Appearance
    Yellow solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for VU 29

  • Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

    Chen Y et al (2007) Mol Pharmacol 71(5) : 1389-98.
    PubMedID: 17303702
  • Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.

    de Paulis T et al (2006) J Med Chem 49(11) : 3332-44.
    PubMedID: 16722652
  • mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning.

    Ayala JE et al (2009) Neuropsychopharmacology 34(9) : 2057-71.
    PubMedID: 19295507