VX 702

(HB1308)

Product overview

  • Name
    VX 702
  • Short description
    Potent, selective ATP-competitive p38 MAPK inhibitor
  • Biological description
    Potent and selective ATP-competitive p38 MAPK inhibitor (Kd values are 3.7 and 17 nM for p38α and p38β respectively). Also inhibits production of IL-6, IL-1β and TNFα (IC50 values are 59, 122 and 99 ng/ml respectively). Exhibits no activity for ERKs and JNKs Displays anti-inflammatory properties.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxa mide
  • Molecular Weight
    404.32
  • Molecular Formula
    C19H12F4N4O2
  • CAS Number
    479543-46-9

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for VX 702

  • Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.

    Goldstein DM et al (2010) J Med Chem 53(6) : 2345-53.
    PubMedID: 19950901
  • An inhibition of p38 mitogen activated protein kinase delays the platelet storage lesion.

    Skripchenko A et al (2013) PLoS One 8(8) : e70732.
    PubMedID: 23967093
  • Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome.

    Ding C (2006) Curr Opin Investig Drugs 7(11) : 1020-5.
    PubMedID: 17117592

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