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Data

Product overview

  • Name
    VX 745
  • Short description
    Potent, selective p38α MAPK inhibitor
  • Biological description
    Potent and selective p38α MAPK inhibitor. Exhibits 20-fold selectivity for p38α over p38β (Ki = 200 nM). Shows little or no activity at other MAP kinases. Inhibits TNFα and IL-1β (IC50 values are 45 and 51 nM respectively). Displays anti-inflammatory properties.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    5-(2,6-Dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one
  • Molecular Weight
    436.26
  • Molecular Formula
    C19H9Cl2F2N3OS
  • CAS Number
    209410-46-8

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for VX 745

  • The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.

    Duffy JP et al (2011) ACS Med Chem Lett 2(10) : 758-63.
    PubMedID: 24900264
  • Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells.

    Bagley MC et al (2007) Bioorg Med Chem Lett 17(18) : 5107-10.
    PubMedID: 17659871
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