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Product overview

  • Name
    VX 745
  • Short description
    Potent, selective p38α MAPK inhibitor
  • Biological description
    Potent and selective p38α MAPK inhibitor. Exhibits 20-fold selectivity for p38α over p38β (Ki = 200 nM). Shows little or no activity at other MAP kinases. Inhibits TNFα and IL-1β (IC50 values are 45 and 51 nM respectively). Displays anti-inflammatory properties.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for VX 745

  • The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.

    Duffy JP et al (2011) ACS Med Chem Lett 2(10) : 758-63.
    PubMedID: 24900264
  • Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells.

    Bagley MC et al (2007) Bioorg Med Chem Lett 17(18) : 5107-10.
    PubMedID: 17659871
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