W-5 hydrochloride

(HB0649)

Product overview

  • Name
    W-5 hydrochloride
  • Short description
    Calmodulin (CaM) antagonist
  • Biological description
    Calmodulin (CaM) antagonist. Reverses the inhibitory effect of insulin via dibutytyl cAMP. A chlorine-deficient inactive analogue of W-7.
  • Alternative names
    W-5; W5
  • Biological action
    Antagonist
  • Our products in action

Properties

  • Chemical name
    N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride
  • Molecular Weight
    342.88
  • Chemical structure
    W-5 hydrochloride  [61714-25-8]
  • Molecular Formula
    C16H22N2O2S.HCl
  • CAS Number
    61714-25-8

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (50mM) or water (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for W-5 hydrochloride

  • Effect of calmodulin antagonists on auxin-induced elongation.

    Raghothama KG et al (1985) Plant Physiol 79(1) : 28-33.
    PubMedID: 16664387
  • W-5 and quin 2-AM reverse the inhibitory effect of insulin on lipolysis due to dibutyryl cAMP.

    Goko H et al (1999) Diabetes Res Clin Pract 44(2) : 101-6.
    PubMedID: 10414928
  • N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.

    Hidaka H et al (1981) Proc Natl Acad Sci U S A 78(7) : 4354-7.
    PubMedID: 6945588

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