WAY 100635 maleate

(HB1790)

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(HB1790)

Data

Product overview

Name
WAY 100635 maleate
Short description
Potent 5-HT_1A receptor antagonist. D₄ receptor agonist.
Biological description
Potent 5-HT_1A receptor antagonist (IC₅₀ value = 2.2 nM). More than 100-fold selective for 5-HT_1A compared with other 5-HT receptors. Also acts as an agonist at D₄ receptor (IC₅₀ value = 16 nM). Active in vivo.
Biological action
Antagonist
Purity
>99%
Citations
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Chemical name
N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate
Molecular Weight
538.64
Chemical structure
Molecular Formula
C₂₅H₃₄N₄O₂.C₄H₄O₄
CAS Number
634908-75-1
PubChem identifier
11957721
SMILES
O=C(C4CCCCC4)N(C3=NC=CC=C3)CCN(CC2)CCN2C1=C(OC)C=CC=C1.O=C(\C=C/C(O)=O)O
InChiKey
XIGAHNVCEFUYOV-BTJKTKAUSA-N

Storage instructions
room temperature (desiccate)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635.

Forster EA et al (1995) Eur J Pharmacol 281(1) : 81-8.
PubMedID: 8566121
WAY-100635 is a potent dopamine D4 receptor agonist.

Chemel BR et al (2006) Psychopharmacology (Berl) 188(2) : 244-51.
PubMedID: 16915381
WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation.

Marona-Lewicka D et al (2009) Behav Pharmacol 20(1) : 114-8.
PubMedID: 19179855

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