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WAY 100635 maleate

(HB1790)
Data

Product overview

  • Name
    WAY 100635 maleate
  • Short description
    Potent 5-HT1A receptor antagonist. D4 receptor agonist.
  • Biological description
    Potent 5-HT1A receptor antagonist (IC50 value = 2.2 nM). More than 100-fold selective for 5-HT1A compared with other 5-HT receptors. Also acts as an agonist at D4 receptor (IC50 value = 16 nM). Active in vivo.
  • Biological action
    Antagonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate
  • Molecular Weight
    538.64
  • Chemical structure
    WAY 100635 maleate  [634908-75-1]
  • Molecular Formula
    C25H34N4O2.C4H4O4
  • CAS Number
    634908-75-1

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for WAY 100635 maleate

  • A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635.

    Forster EA et al (1995) Eur J Pharmacol 281(1) : 81-8.
    PubMedID: 8566121
  • WAY-100635 is a potent dopamine D4 receptor agonist.

    Chemel BR et al (2006) Psychopharmacology (Berl) 188(2) : 244-51.
    PubMedID: 16915381
  • WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation.

    Marona-Lewicka D et al (2009) Behav Pharmacol 20(1) : 114-8.
    PubMedID: 19179855
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