Product overview

Name Wedelolactone
Purity >98%
Description Selective IKKα and IKKβ kinase activity inhibitor. NF-κB inhibitor.
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Biological Data

Biological description Cell permeable, selective and irreversible IKKalpha and beta kinase activity inhibitor. NF-kappaB inhibitor. Blocks phosphorylation and degradation of IkappaBalpha. Antihepatotoxic. 5-Lipoxygenase (5-LOX) inhibitor. Anti-inflammatory. HIV-1 integrase inhibitor. Anticancer and antiproliferative compound. Modulates androgen receptor (AR) activation. Apoptosis inducer via downregulation of PKCepsilon. DNA topoisomerase IIalpha inhibitor. G protein-coupled receptor-35 (GPR35) agonist. Inhibits adipogenic differentiation of mesenchymal stem cells (hAMSCs) through ERK pathway. STAT1 protein dephosphorylation inhibitor. Antifibrotic.

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 7-Methoxy-5,11,12-trihydroxy-coumestan
Molecular Weight 314.2
Chemical structure Wedelolactone [524-12-9] Chemical Structure
CAS Number 524-12-9
SMILES COc1cc(O)c2c(OC(=O)c3c2oc4cc(O)c(O)cc34)c1
InChiKey XQDCKJKKMFWXGB-UHFFFAOYSA-N
Appearance Yellow to amber crystalline powder