Product overview

  • Name
    WHI-P 154
  • Short description
    Non-selective JAK3 inhibitor and potent EGFR inhibitor. Induces neural progenitor cell differentiation.
  • Biological description
    Non-selective JAK3 inhibitor (IC50 = 1.8 µM), also acts as a potent EGFR kinase inhibitor (IC50 = 4 nM). Inhibits expression of iNOS and production of NO. Also induces neural progenitor cell differentiation. Shows apoptotic and anti-tumor actions.
  • Alternative names
    WHI-P154
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
  • Molecular Weight
    376.2
  • Chemical structure
    WHI-P 154  [211555-04-3]
  • Molecular Formula
    C16H14BrN3O3
  • CAS Number
    211555-04-3

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for WHI-P 154

  • The specificity of JAK3 kinase inhibitors.

    Changelian PS et al (2008) Blood 111(4) : 2155-7.
    PubMedID: 18094329
  • Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin: differential effects on the expression of iNOS, COX-2 and TNF-alpha.

    Sareila O et al (2008) Int Immunopharmacol 8(1) : 100-8.
    PubMedID: 18068105
  • 4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells.

    Narla RK et al (1998) Clin Cancer Res 4(6) : 1405-14.
    PubMedID: 9626456