WIKI4

(HB0657)

Product overview

  • Name
    WIKI4
  • Short description
    Potent tankyrase inhibitor. Wnt signaling inhibitor.
  • Biological description
    Potent tankyrase (TNKS) inhibitor (IC50 values are 15 and 26 nM for TNKS2 and TNKS1 respectively). Inhibits the auto-ADP-ribosylation of tankyrase and Wnt/β-catenin signaling in cancer cell lines and embryonic stem cells (EC50 = 75 nM).
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyr idinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz [de]isoquinoline-1,3(2H)-dione
  • Molecular Weight
    521.59
  • Chemical structure
    WIKI4  [838818-26-1]
  • Molecular Formula
    C29H23N5O3S
  • CAS Number
    838818-26-1

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (20mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for WIKI4

  • WIKI4, a novel inhibitor of tankyrase and Wnt/ã?-catenin signaling.

    James RG et al (2012) PLoS One 7(12) : e50457.
    PubMedID: 23227175
  • Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4.

    Haikarainen T et al (2013) PLoS One 8(6) : e65404.
    PubMedID: 23762361