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Biological Data

Biological description Potent tankyrase (TNKS) inhibitor (IC50 values are 15 and 26 nM for TNKS2 and TNKS1 respectively). Inhibits the auto-ADP-ribosylation of tankyrase and Wnt/β-catenin signaling in cancer cell lines and embryonic stem cells (EC50 = 75 nM).

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (20mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >98%
Chemical name 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyr idinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz [de]isoquinoline-1,3(2H)-dione
Molecular Weight 521.59
Chemical structure WIKI4  [838818-26-1] Chemical Structure
Molecular Formula C29H23N5O3S
CAS Number 838818-26-1
PubChem identifier 2984337
SMILES O=C(C5=C4C(C6=O)=CC=CC4=CC=C5)N6CCCSC1=NN=C(C3=CC=NC=C3)N1C2=CC=C(OC)C=C2
InChiKey RNUXIZKXJOGYQP-UHFFFAOYSA-N

References for WIKI4

References are publications that support the biological activity of the product
  • Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4.

    Haikarainen T et al (2013) PLoS One 8(6) : e65404.
  • WIKI4, a novel inhibitor of tankyrase and Wnt/ã?-catenin signaling.

    James RG et al (2012) PLoS One 7(12) : e50457.

2 Item(s)