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Product overview

  • Name
  • Short description
    Potent, selective N-WASP inhibitor
  • Biological description
    Potent and selective neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor that interacts with GTPase- binding domain. Inhibits Arp2/3 complex activation. Decreases cellular ATP levels and inhibits cytokinesis but not mitosis. A carbazole derivative.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    3,6-Dibromo-α-[(dimethylamino)methyl ]-9H-cabazole-9-ethanol
  • Molecular Weight
  • Chemical structure
    Wiskostatin  [253449-04-6]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Wiskostatin

  • Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.

    Peterson JR et al (2004) Nat Struct Mol Biol 11(8) : 747-55.
    PubMedID: 15235593
  • Inhibition of cytokinesis by wiskostatin does not rely on N-WASP/Arp2/3 complex pathway.

    Bompard G et al (2008) BMC Cell Biol 9 : 42
    PubMedID: 18667055
  • N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels.

    Guerriero CJ et al (2007) Am J Physiol Cell Physiol 292(4) : C1562-6.
    PubMedID: 17092993
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