Product overview

Name Wiskostatin
Purity >99%
Description Potent, selective N-WASP inhibitor
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Biological Data

Biological description Potent and selective neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor that interacts with GTPase- binding domain. Inhibits Arp2/3 complex activation. Decreases cellular ATP levels and inhibits cytokinesis but not mitosis. A carbazole derivative.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >99%
Chemical name 3,6-Dibromo-α-[(dimethylamino)methyl ]-9H-cabazole-9-ethanol
Molecular Weight 426.15
Chemical structure Wiskostatin  [253449-04-6] Chemical Structure
Molecular Formula C17H18Br2N2O
CAS Number 253449-04-6
PubChem identifier 2775510
SMILES BrC(C=C3)=CC1=C3N(CC(O)CN(C)C)C2=C1C=C(Br)C=C2
InChiKey XUBJEDZHBUPBKL-UHFFFAOYSA-N

References for Wiskostatin

References are publications that support the biological activity of the product
  • Inhibition of cytokinesis by wiskostatin does not rely on N-WASP/Arp2/3 complex pathway.

    Bompard G et al (2008) BMC Cell Biol 9 : 42
  • N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels.

    Guerriero CJ et al (2007) Am J Physiol Cell Physiol 292(4) : C1562-6.
  • Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.

    Peterson JR et al (2004) Nat Struct Mol Biol 11(8) : 747-55.

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