In my cart

You have no items in your shopping cart.


Product overview

  • Name
  • Short description
    Highly potent PORCN inhibitor. Induces iPSC cardiomyocytes differentiation.
  • Biological description
    Potent, cell permeable PORCN inhibitor (IC50 = 74 pM). >100-fold more potent than IWP1. Potently inhibits Wnt/β-catenin signaling. Also induces induced pluripotent stem cell (iPSC) cardiomyocyte differentiation when used in combination with CHIR 99021.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    4-(2-Methyl-4-pyridinyl)-N-[4-(3-py ridinyl)phenyl]benzeneacetamide
  • Molecular Weight
  • Chemical structure
    Wnt-C59 |  [1243243-89-1]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (20mM) or ethanol (20mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Wnt-C59

  • Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.

    Proffitt et al (2013) Cancer Res 73(2) : 502-7
    PubMedID: 23188502
  • Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation.

    Youssef et al (24930130) Nat Cell Biol 14(12) : 1282-94
    PubMedID: 24930130
  • Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

    Chen et al (2009) Nat Chem Biol 5(2) : 100-7
    PubMedID: 19125156
Support & Resources