In my cart

You have no items in your shopping cart.

Wortmannin

(HB2778)
Data

Product overview

  • Name
    Wortmannin
  • Short description
    Potent, selective, irreversible PI3-K inhibitor
  • Biological description
    Potent, selective, non-compettive and irreversible PI3-K inhibitor (IC50 = 2-4 nM). Also inhibits PI3-K related kinases and PLK1. Cell permeable. Shows variety of biological actions.
  • Alternative names
    SL-2052
  • Biological action
    Inhibitor
  • Citations

Properties

  • Chemical name
    (1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11 b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-f uro[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6, 9-trione
  • Molecular Weight
    428.44
  • Molecular Formula
    C23H24O8
  • CAS Number
    19545-26-7

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Wortmannin

  • Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

    Ui et al (1995) Trends Biochem Sci 20(8) : 303-7
    PubMedID: 7667888
  • Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

    Powis et al (1994) Cancer Res 54(9) : 2419-23
    PubMedID: 8162590
  • Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

    Liu et al (2005) Chem Biol 12(1) : 99-107
    PubMedID: 15664519
Support & Resources

Reviews & Product Guides