XAP044

(HB1599)

Product overview

  • Name
    XAP044
  • Short description
    Novel, selective mGlu7 antagonist
  • Biological description
    Novel, selective mGlu7 receptor antagonist. Shows novel molecular mode of pharmacological action. Acts as an orthosteric like antagonist and binds at a binding pocket in the Venus flytrap domain. Inhibits long term potentiation (LTP) in the lateral amygdala in a mGlu7 dependent manner (IC50 = 88 nM). Shows anti-stress, anxiolytic and anti-depressant actions. Blood-brain barrier permeable.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
  • Molecular Weight
    380.13
  • Chemical structure
    XAP 044  [196928-50-4]
  • Molecular Formula
    C15H9IO4
  • CAS Number
    196928-50-4
  • PubChem identifier
    5428913
  • SMILES
    C1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I
  • InChi
    InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
  • InChiKey
    XXZKJJYWINSUMJ-UHFFFAOYSA-N
  • MDL number
    MFCD00525548

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    Soluble in DMSO (100mM) and in ethanol (20mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for XAP044

  • Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.

    Gee CE et al (2014) J Biol Chem 289(16) : 10975-87.
    PubMedID: 24596089