XAP044

(HB1599)

Order: HB1599

Pack	Price	Qty
10mg	$132
50mg	$509

(HB1599)

Data

Product overview

Name
XAP044
Short description
Novel, selective mGlu₇ antagonist
Biological description
Novel, selective mGlu₇ receptor antagonist. Shows novel molecular mode of pharmacological action. Acts as an orthosteric like antagonist and binds at a binding pocket in the Venus flytrap domain. Inhibits long term potentiation (LTP) in the lateral amygdala in a mGlu₇ dependent manner (IC₅₀ = 88 nM). Shows anti-stress, anxiolytic and anti-depressant actions. Blood-brain barrier permeable.
Biological action
Antagonist
Purity
>98%
Citations
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Chemical name
7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
Molecular Weight
380.13
Chemical structure
Molecular Formula
C₁₅H₉IO₄
CAS Number
196928-50-4
PubChem identifier
5428913
SMILES
C1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I
InChi
InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
InChiKey
XXZKJJYWINSUMJ-UHFFFAOYSA-N
MDL number
MFCD00525548

Storage instructions
-20°C
Solubility overview
Soluble in DMSO (100mM) and in ethanol (20mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.

Gee CE et al (2014) J Biol Chem 289(16) : 10975-87.
PubMedID: 24596089

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