XAP044
(HB1599)- Data
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Data
Product overview
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NameXAP044
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Short descriptionNovel, selective mGlu7 antagonist
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Biological descriptionNovel, selective mGlu7 receptor antagonist. Shows novel molecular mode of pharmacological action. Acts as an orthosteric like antagonist and binds at a binding pocket in the Venus flytrap domain. Inhibits long term potentiation (LTP) in the lateral amygdala in a mGlu7 dependent manner (IC50 = 88 nM). Shows anti-stress, anxiolytic and anti-depressant actions. Blood-brain barrier permeable.
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Biological actionAntagonist
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Purity>98%
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Properties
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Chemical name7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
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Molecular Weight380.13
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Chemical structure
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Molecular FormulaC15H9IO4
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CAS Number196928-50-4
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PubChem identifier5428913
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SMILESC1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I
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InChiInChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
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InChiKeyXXZKJJYWINSUMJ-UHFFFAOYSA-N
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MDL numberMFCD00525548
Storing and Using Your Product
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Storage instructions-20°C
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Solubility overviewSoluble in DMSO (100mM) and in ethanol (20mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for XAP044
Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.
Gee CE et al (2014) J Biol Chem 289(16) : 10975-87.PubMedID: 24596089
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