XAP044

Product overview

• Name
  XAP044
• Short description
  Novel, selective mGlu₇ antagonist
• Biological description
  Novel, selective mGlu₇ receptor antagonist. Shows novel molecular mode of pharmacological action. Acts as an orthosteric like antagonist and binds at a binding pocket in the Venus flytrap domain. Inhibits long term potentiation (LTP) in the lateral amygdala in a mGlu₇ dependent manner (IC₅₀ = 88 nM). Shows anti-stress, anxiolytic and anti-depressant actions. Blood-brain barrier permeable.
• Biological action
  Antagonist
• Purity
  >98%
• Our products in action
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Properties

• Chemical name
  7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
• Molecular Weight
  380.13
• Chemical structure
  
• Molecular Formula
  C₁₅H₉IO₄
• CAS Number
  196928-50-4
• PubChem identifier
  5428913
• SMILES
  C1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I
• InChi
  InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
• InChiKey
  XXZKJJYWINSUMJ-UHFFFAOYSA-N
• MDL number
  MFCD00525548

Storing and Using Your Product

• Storage instructions
  -20°C
• Solubility overview
  Soluble in DMSO (100mM) and in ethanol (20mM)
• Important
  This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Reviews & Product Guides

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