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Data

Product overview

  • Name
    XAV 939
  • Short description
    Potent tankyrase inhibitor. Wnt/β-catenin signaling inhibitor.
  • Biological description

    Potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM at TNKS2 and TNKS1 respectively).

    XAV 939 stabilizes Axin to stimulate β-catenin degradation to inhibit the Wnt-β-catenin signalling pathway.

    Displays antiproliferative and apoptotic inducing properties. Also involved in neuronal development.

    Robustly induces cardiomyogenesis in mouse embryonic stem (ES) cells.

  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
  • Molecular Weight
    312.31
  • Chemical structure
    XAV 939  [284028-89-3]
  • Molecular Formula
    C14H11F3N2OS
  • CAS Number
    284028-89-3
  • PubChem identifier
    2726824
  • SMILES
    C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
  • Source
    Synthetic
  • InChi
    InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
  • InChiKey
    KLGQSVMIPOVQAX-UHFFFAOYSA-N
  • MDL number
    MFCD16879017

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (20mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for XAV 939

  • XAV939 inhibits the stemness and migration of neuroblastoma cancer stem cells via repression of tankyrase 1.

    Tian X et al (2014) Int J Oncol 45(1) : 121-8.
    PubMedID: 24789807
  • Modelling of a targeted nanotherapeutic 'stroma' to deliver the cytokine LIF, or XAV939, a potent inhibitor of Wnt-β-catenin signalling, for use in human fetal dopaminergic grafts in Parkinson's disease.

    Zhao JW et al (2014) Dis Model Mech 7(10) : 1193-203.
    PubMedID: 25085990
  • Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939.

    Kirby CA et al (2012) Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 2) : 115-8.
    PubMedID: 22297980
  • XAV939, a tankyrase 1 inhibitior, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wnt/β-catenin signaling pathway.

    Tian XH et al (2013) J Exp Clin Cancer Res 32 : 100
    PubMedID: 24308762
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