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XE 991 dihydrochloride

(HB1090)
Data

Product overview

  • Name
    XE 991 dihydrochloride
  • Short description
    Potent, selective Kv7 channel blocker
  • Biological description
    Potent and selective Kv7 (KCNQ) channel blocker. Inhibits KCNQ type IM (M-current), Kv4.3 and Kv1.2 (IC50 values are 0.71, >43 and>100 µM).Blocks KCNQ1 current (Kd = 78 µM). Enhances ACh release (EC50 = 490 nM). Shows cognitive enhancing actions.
  • Biological action
    Blocker
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride
  • Molecular Weight
    449.37
  • Chemical structure
    XE 991 dihydrochloride  [122955-42-4]
  • Molecular Formula
    C26H20N2O.2HCl
  • CAS Number
    122955-42-4
  • PubChem identifier
    45073462
  • SMILES
    C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl
  • InChi
    InChI=1S/C26H20N2O.2ClH/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25;;/h1-16H,17-18H2;2*1H
  • InChiKey
    WOGWMARIFDNZON-UHFFFAOYSA-N
  • MDL number
    MFCD05662331

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for XE 991 dihydrochloride

  • Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine.

    Zaczek R et al (1998) J Pharmacol Exp Ther 285(2) : 724-30.
    PubMedID: 9580619
  • Characterization of M-current in ventral tegmental area dopamine neurons.

    Koyama S et al (2006) J Neurophysiol 96(2) : 535-43.
    PubMedID: 16394077
  • Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991.

    Wang HS et al (2000) Mol Pharmacol 57(6) : 1218-23.
    PubMedID: 10825393
  • The M-current inhibitor XE991 decreases the stimulation threshold for long-term synaptic plasticity in healthy mice and in models of cognitive disease.

    Fontán-Lozano A et al (2011) Hippocampus 21(1) : 22-32.
    PubMedID: 19921704
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