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(-)-Xestospongin C


Product overview

  • Name
    (-)-Xestospongin C
  • Short description
    Potent IP3 receptor inhibitor
  • Biological description
    Potent IP3 receptor inhibitor. Inhibits P3-mediated Ca2+ release (IC50 = 358 nM). Selective for IP3 receptors over ryanodine receptors. Inhibits sarcoplasmic/endoplasmic reticulum Ca2+ ATPase SERCA pump.
  • Biological action
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    (-)-Xestospongin C  [88903-69-9]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in DMSO (2mM) or ethanol (2mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (-)-Xestospongin C

  • Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor.

    Gafni J et al (1997) Neuron 19(3) : 723-33.
    PubMedID: 9331361
  • Xestospongin C is a potent inhibitor of SERCA at a vertebrate synapse.

    Castonguay A et al (2002) Cell Calcium 32(1) : 39-47.
    PubMedID: 12127061
  • Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca(2+) pumps.

    De Smet P et al (1999) Cell Calcium 26(1-2) : 9-13.
    PubMedID: 10892566
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