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ROCK inhibitor Y-27632


Product overview

  • Name
    ROCK inhibitor Y-27632
  • Short description
    Y-27632 is a selective ROCK inhibitor
  • Biological description

    The ROCK inhibitor Y-27632 is a selective and cell permeable inhibitor of the Rho-associated protein kinase (ROCK) (Ki values are 0.14, 26 ,25 and >250 µM at p160ROCK, PKC, PKA and MLCK respectively).

    Y-27632 has many biological actions and is an important small molecule modulator of stem cells. It diminishes hES and hiPSC dissociation-induced apoptosis, enhances survival and colony formation of dissociated hESC without affecting pluripotency or self-renewal.

    Y-27632 also improves hESC and iPSCs postthaw viability and survival rate during cryopreservation.

    Additionally, Y-27632 inhibits smooth muscle contractility and shows antihypertensive effect. 

  • Alternative names
    Y27632 dihydrochloride
  • Biological action
  • Purity
  • Customer comments

    The ROCK inhibitor Y-27632 is working as expected. Verified customer, University of Louisville

  • Citations



  • Chemical name
    trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
  • Molecular Weight
  • Chemical structure
    Y-27632 dihydrochloride [129830-38-2]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ROCK inhibitor Y-27632

  • Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.

    Ishizaki T et al (2000) Mol Pharmacol 57(5) : 976-83.
    PubMedID: 10779382
  • A ROCK inhibitor permits survival of dissociated human embryonic stem cells.

    Watanabe et al (2007) Nat Biotechnol 25(6) : 681-6.
    PubMedID: 17529971
  • Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors.

    Koyanagi et al (2008) J Neurosci Res 86(2) : 270-80
    PubMedID: 17828770
  • Inhibition of ROCK improves survival of human embryonic stem cell-derived cardiomyocytes after dissociation.

    Braam et al (2010) Ann N Y Acad Sci 1188 : 52-7
    PubMedID: 20201886
Support & Resources


  • Verified customer, University of Louisville

    The Y-27632 is working as expected.