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YM 298198 hydrochloride


Product overview

  • Name
    YM 298198 hydrochloride
  • Short description
    Potent, selective, non-competitive mGlu1 antagonist
  • Biological description
    Potent, selective and non-competitive mGlu1 receptor antagonist (IC50 = 16 nM). Shows antiproliferative effects in cancers expressing mGlu1 receptor.
  • Alternative names
    YM 298198
  • Biological action
  • Purity
  • Citations


  • Chemical name
    6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
  • Molecular Weight
  • Chemical structure
    YM 298198 hydrochloride  [748758-45-4]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChi
  • InChiKey
  • MDL number

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for YM 298198 hydrochloride

  • Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor ty

    Kohara A et al (2005) J Pharmacol Exp Ther 315(1) : 163-9.
    PubMedID: 15976016
  • Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.

    Fukunaga I et al (2007) Br J Pharmacol 151(6) : 870-6.
    PubMedID: 17502847
  • Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer.

    Speyer CL et al (2014) PLoS One 9(3) : e88830.
    PubMedID: 24633367
Our products in action
The following papers have cited the use of YM 298198 hydrochloride (HB0664) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.

    Sanderson et al (2018) Cell Rep. 25(13) : 3631-3646
    PubMedID: 30590038
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