YM 298198 hydrochloride

(HB0664)

Product overview

  • Name
    YM 298198 hydrochloride
  • Short description
    Potent, selective, non-competitive mGlu1 antagonist
  • Biological description
    Potent, selective and non-competitive mGlu1 receptor antagonist (IC50 = 16 nM). Shows antiproliferative effects in cancers expressing mGlu1 receptor.
  • Alternative names
    YM 298198
  • Biological action
    Antagonist
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
  • Molecular Weight
    378.92
  • Chemical structure
    YM 298198 hydrochloride  [748758-45-4]
  • Molecular Formula
    C18H22N4OS.HCl
  • CAS Number
    748758-45-4
  • PubChem identifier
    45073464
  • SMILES
    CC1=C(SC2=NC3=C(N12)C=C(C=C3)N)C(=O)N(C)C4CCCCC4.Cl
  • InChi
    InChI=1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H
  • InChiKey
    WYTJVUVCSUWZTH-UHFFFAOYSA-N
  • MDL number
    MFCD08703122

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for YM 298198 hydrochloride

  • Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor ty

    Kohara A et al (2005) J Pharmacol Exp Ther 315(1) : 163-9.
    PubMedID: 15976016
  • Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.

    Fukunaga I et al (2007) Br J Pharmacol 151(6) : 870-6.
    PubMedID: 17502847
  • Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer.

    Speyer CL et al (2014) PLoS One 9(3) : e88830.
    PubMedID: 24633367