YM 298198 hydrochloride

(HB0664)
Technical documents: SDS CoA Datasheet

Product overview

Name YM 298198 hydrochloride
Alternative names YM 298198
Purity >99%
Description Potent, selective, non-competitive mGlu1 antagonist
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YM 298198 hydrochloride product vial image | Hello Bio

Biological Data

Biological description Potent, selective and non-competitive mGlu1 receptor antagonist (IC50 = 16 nM). Shows antiproliferative effects in cancers expressing mGlu1 receptor.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
Molecular Weight 378.92
Chemical structure YM 298198 hydrochloride  [748758-45-4] Chemical Structure
Molecular Formula C18H22N4OS.HCl
CAS Number 748758-45-4
PubChem identifier 45073464
SMILES CC1=C(SC2=NC3=C(N12)C=C(C=C3)N)C(=O)N(C)C4CCCCC4.Cl
InChi InChI=1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H
InChiKey WYTJVUVCSUWZTH-UHFFFAOYSA-N
MDL number MFCD08703122

References for YM 298198 hydrochloride

References are publications that support the biological activity of the product
  • Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer.

    Speyer CL et al (2014) PLoS One 9(3) : e88830.
  • Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.

    Fukunaga I et al (2007) Br J Pharmacol 151(6) : 870-6.
  • Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor ty

    Kohara A et al (2005) J Pharmacol Exp Ther 315(1) : 163-9.

3 Item(s)

Publications
These publications cite the use of YM 298198 hydrochloride purchased from Hello Bio:
  • Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron

    Hikima T et al (2021) Cell Rep 35(1) : 108951
    PubMedID: 33826884
  • The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.

    Sanderson et al (2018) Cell Rep. 25(13) : 3631-3646
    PubMedID: 30590038

2 Item(s)