In my cart

You have no items in your shopping cart.



Product overview

  • Name
  • Short description
    Irreversible, selective caspase 3 inhibitor
  • Biological description
    Irreversible and selective caspase 3 inhibitor (IC50 = 0.13 µM). Cell permeable. Exhibits no activity at cathespin B and cathespin L. Displays neuroprotective properties and inhibits apoptosis.
  • Biological action
  • Citations


  • Chemical name
  • Molecular Weight
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (13.37mg/ml)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Z-DEVD-FMK

  • Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway.

    Kugawa F et al (2000) Biol Pharm Bull 23(8) : 930-5.
    PubMedID: 10963298
  • Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures.

    Henshall DC et al (2000) J Neurochem 74(3) : 1215-23.
    PubMedID: 10693954
  • Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3.

    Brockstedt E et al (1998) J Biol Chem 273(43) : 28057-64.
    PubMedID: 9774422
  • Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.

    Lee J et al (2010) ACS Chem Biol 5(2) : 233-43.
    PubMedID: 20017516
Support & Resources

Reviews & Product Guides