Z-Leu-Leu-Leu-B(OH)2

(HB4134)

Product overview

  • Name
    Z-Leu-Leu-Leu-B(OH)2
  • Short description
    Highly potent, selective, cell permeable proteasome inhibitor. More potent than MG-132.
  • Biological description
    Highly potent, selective, reversible cell permeable proteasome inhibitor. More potent than MG-132. Inhibits chymotrypsin- and caspase-like peptidase activity of the proteasome. Also shows calpain and cathepsin inhibitor. Activates autophagy and induces apoptosis.
  • Alternative names
    MG-262 | ZL3B | Z-LLL-B(OH)2
  • Biological action
    Inhibitor
  • Purity
    >95%
  • Citations

Properties

  • Chemical name
    Z-Leu-Leu-Leu-B(OH)2
  • Molecular Weight
    491.4
  • Molecular Formula
    C25H42BN3O6
  • CAS Number
    179324-22-2
  • InChiKey
    MWKOOGAFELWOCD-FKBYEOEOSA-N
  • Appearance
    Solid lyophilized powder

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Z-Leu-Leu-Leu-B(OH)2

  • Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL3B.

    Reynolds JM et al (2007) BMC Clin Pharmacol. 23 : 7-13
  • Proteasome inhibition reduces proliferation, collagen expression, and inflammatory cytokine production in nasal mucosa and polyp fibroblasts.

    Pujols L et al (2012) J Pharmacol Exp Ther 343(1) : 184-97
    PubMedID: 22787116
  • Identification of the proteasome inhibitor MG262 as a potent ATP-dependent inhibitor of the Salmonella enterica serovar Typhimurium Lon protease.

    Frase H et al (2006) Biochemistry 45(27) : 8264-74
    PubMedID: 16819825
  • Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.

    Das I et al (2015) Science 348(6231) : 239-42
    PubMedID: 25859045

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