Z-VDVAD-FMK

(HB1286)

Product overview

  • Name
    Z-VDVAD-FMK
  • Short description
    Irreversible caspase 2 inhibitor
  • Biological description
    Irreversible caspase 2 inhibitor. Significantly reduces cell detachment, caspase-2 and -3 activity, DNA ladders, and proteolytic cleavage of PARP. Displays inhibitory apoptotic actions.
  • Biological action
    Inhibitor
  • Citations

Properties

  • Chemical name
    Benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone
  • Molecular Weight
    695.74
  • Molecular Formula
    C32H46FN5O11

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (13.791mg/ml)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Z-VDVAD-FMK

  • Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells.

    Gamen S et al (2000) Exp Cell Res 258(1) : 223-35.
    PubMedID: 10912804
  • Caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells.

    Meguro T et al (2001) Stroke 32(2) : 561-6.
    PubMedID: 11157197
  • Upstream control of apoptosis by caspase-2 in serum-deprived primary neurons.

    Chauvier D et al (2005) Apoptosis 10(6) : 1243-59.
    PubMedID: 16215683

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