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Biological Data

Biological description Irreversible caspase 2 inhibitor. Significantly reduces cell detachment, caspase-2 and -3 activity, DNA ladders, and proteolytic cleavage of PARP. Displays inhibitory apoptotic actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (13.791mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name Benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone
Molecular Weight 695.74
Molecular Formula C32H46FN5O11
SMILES [H]N([C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1

References for Z-VDVAD-FMK

References are publications that support the biological activity of the product
  • Upstream control of apoptosis by caspase-2 in serum-deprived primary neurons.

    Chauvier D et al (2005) Apoptosis 10(6) : 1243-59.
  • Caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells.

    Meguro T et al (2001) Stroke 32(2) : 561-6.
  • Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells.

    Gamen S et al (2000) Exp Cell Res 258(1) : 223-35.

3 Item(s)